Research into better immune modulators
It is a disgrace that many liver, heart, lung, pancreas, intestinal transplant pts need new kidneys ten plus years post transplant due to tacrolimus (prograf). In fact, it is one of the most common side effects of the drug - kidney toxicity - and I am surprised that scientists and industry have not brought fwd better drugs in so many years. Yes, we have long acting tac - envarsus - but that is merely symptomatic improvement vs mechanistic, and Belatacept is only approved for kidney transplants and is not even used much.
I want to scan the literature in immune oncology and tolerance research to see if there are drugs that could be repositioned for transplant drugs - I wonder if there is more interest for this and if we could try to make this a project for TransplantLyfe! Raise funds and lead this effort… then start a company or introduce the project to a manor pharma?